Endocrine Abstracts

Introduction: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy arising from the adrenal cortex often with unexpected biological behavior. It can occur at any age, with two peaks of incidence: in the first and between fifth and seventh decades of life. Although ACC are mostly hormonally active, precursors and metabolites may be also produced by dedifferentiated and immature malignant cells.Case report: We report a rare and challenging case of...

Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal-dominant tumor syndrome associated with a wide tumor spectrum, in endocrine and nonendocrine tissues, key association being pituitary, parathyroid and enteropancreatic neuroendocrine tumors. Management of MEN1 is challenging because of its polymorphic, variable phenotypic expression.Case report: Here, we present the case of a 68 year old patient diagnosed in 2004 with an 18 mm ist...

Introduction: Western countries present a gradual decline in male reproductive function. The decline in testosterone levels and sperm production witnessed over the past five decades, has been ascribed to environmental factors and unhealthy behaviors. Substance and drug usage is recognized as a detrimental lifestyle choice, that can interfere with the processes of steroidogenesis and spermatogenesis. Hypogonadism due to substance and drug abuse can be reversible.<p class="a...

Introduction: Multiple endocrine neoplasia type 2A is an autosomal dominant disorder, caused by mutations in the RET proto-oncogene. The genetic testing may help us in the early identification of carriers, and it can guide us on the follow-up and on the treatment. Thus, we can significantly reduce the morbidity and mortality of this syndrome. We will illustrate a case and highlight the importance of follow-up in a MEN2A patient.Case report: A 41-year-old...